ABSTRACT
BACKGROUND/AIMS: Susceptibility to organ damage induced by alcohol may be related to inherited variations (polymorphisms) in alcohol-metabolizing enzymes, or polymorphisms affecting cytokines. The aim of this study was to compare the genotype and allelic frequencies of ADH2, ADH3, ALDH2, cytochrome P450-2E1, IL-1, IL-6, IL-8 and tumor necrosis factor-alpha in patients with alcoholic pancreatitis and alcoholic liver cirrhosis with those of controls. METHODS: We determined the polymorphism of genes of the above-mentioned alcohol-metabolizing enzymes and cytokines in 29 alcoholic pancreatitis patients (AP), 22 alcoholic liver cirrhosis patients (LC) and 100 healthy blood donors (control). The genotypes were characterized by restriction fragment length polymorphism after amplification of genomic DNA by polymerase chain reaction. RESULTS: The allelic frequency of CYP2E1*c2 was significantly different in three groups (AP: LC: Control=0.224: 0.136: 0.320, p<0.05). There was no significant difference in the other genotypes or allelic frequencies of the three groups. The allelic frequencies of CYP2E1*c2 and ALDH2*2 were more frequent in the control than patients with alcoholic liver cirrhosis (LC: Control=0.136: 0.320, p<0.05, LC: Control= 0.114: 0.265, p<0.05). Allelic frequencies of ADH2 was statisitcally different between LC and control (ADH2*1; LC: Control=0.727: 0.495, ADH2*2; 0.227: 0.360, ADH2*3; 0.046: 0.145, p<0.05). CONCLUSIONS: There was no difference in the frequencies of genotype and allele of enzymes and cytokines among the three groups. However, frequency of ADH2*1 was significantly higher and those of CYP2E1*c2 and ALDH2*2 were significantly lower than LC group than control.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Alcohol Dehydrogenase/genetics , Aldehyde Dehydrogenase/genetics , Cytochrome P-450 CYP2E1/genetics , Cytokines/genetics , English Abstract , Gene Frequency , Genotype , Liver Cirrhosis, Alcoholic/genetics , Pancreatitis, Alcoholic/genetics , Polymorphism, GeneticABSTRACT
Mucinous adenocarcinoma is a rare histologic type of gastric carcinoma. Most mucinous gastric carcinoma is diagnosed by histology after surgical resection. However, in this report, we preoperatively predicted the type of a tumor (mucinous type) from its characteristic endoscopic finding. An endoscopic examination showed a cauliflower-like mass on the upper body of the posterior wall. At first we could not find the mass because it was covered with a thick mucin-like substance. After gastric lavage and mucin aspiration we found a tumor mass which was surrounded with a characteristic mucin pool. Abdominal CT showed a 6 cm sized-mass connected with the gastric fundus. Total gastrectomy with esophagojejunostomy was performed. The pathology of the tumor proved to be a mucinous adenocarcinoma.
Subject(s)
Adenocarcinoma , Adenocarcinoma, Mucinous , Gastrectomy , Gastric Fundus , Gastric Lavage , Gastric Mucins , Mucins , Pathology , Tomography, X-Ray ComputedABSTRACT
Upper gastrointestinal bleeding is one of the most common complications in patients with chronic renal failure. Common causes are peptic ulcer, gastritis, duodenitis, esophagitis, Mallory-Weiss tear, and angiodysplasia. However, gastric polyp is a rare cause of upper gastrointestinal bleeding. We diagnosed a bleeding hyperplastic polyp in chronic renal failure patient with melena. He had a bleeding polyp with a Y-shaped stalk. This polyp was treated effectively by endoscopic snare polypectomy.
Subject(s)
Humans , Angiodysplasia , Duodenitis , Esophagitis , Gastritis , Hemorrhage , Kidney Failure, Chronic , Mallory-Weiss Syndrome , Melena , Peptic Ulcer , Polyps , SNARE ProteinsABSTRACT
Upper gastrointestinal bleeding is one of the most common complications in patients with chronic renal failure. Common causes are peptic ulcer, gastritis, duodenitis, esophagitis, Mallory-Weiss tear, and angiodysplasia. However, gastric polyp is a rare cause of upper gastrointestinal bleeding. We diagnosed a bleeding hyperplastic polyp in chronic renal failure patient with melena. He had a bleeding polyp with a Y-shaped stalk. This polyp was treated effectively by endoscopic snare polypectomy.
Subject(s)
Humans , Angiodysplasia , Duodenitis , Esophagitis , Gastritis , Hemorrhage , Kidney Failure, Chronic , Mallory-Weiss Syndrome , Melena , Peptic Ulcer , Polyps , SNARE ProteinsABSTRACT
BACKGROUND: Tuberculous pleurisy has been treated with a combined regimen of corticosteroids-antimicrobial therapy. But whether such combination therapy add to benefits is unknown. We evaluate the effects of corticosteroid and its routine application in relief of clinical symptoms, absorption of pleural effusion, and pleural adhesions. METHODS: A prospective, randomized study of the role of corticosteroid in the treatment of tuberculous pleurisy was performed in 83 patients(nonsteroid group:50 patients, steroid group: 33 patients) from June, 1991 to September, 1994. RESULTS: 1) The mean duration from symptoms(fever, chest pain, dyspnea) to relief was 3.8 days in the steroid group, and 7.4 days in the nonsteroid group(P0.05). 3) The incidence of pleural adhesions was 17/33(51.5%) in the steroid group and 32/50(64%) in the nonsteroid group(p>0.05). 4) Side effects of corticosteroids were observed in only one patient causing epigastric pain and discontinuation of drug. CONCLUSION: Corticosteroid exert benefitial role in the more rapid relief of clinical symptoms to patients with tuberculous pleurisy, but absortion of pleural effusion and occurrence of pleural adhesions was not influenced significantly. Therefore, its routine application should be reevaluated.